ASH2L Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-10964

Overview

Synonyms ASH 2,Ash2 (absent small or homeotic) like,Ash2 (absent,small,or homeotic) like (Drosophila),ASH2,ASH2 LIKE,ASH2 like protein,ASH2-like protein,Ash2l,ASH2L,ASH2L1>,ASH2L2,Bre 2,Bre2,Discs 2-like,Drosophila absent,small,or homeotic,Drosophila ASH2-like,Set1/Ash2 histone methyltransferase complex subunit ASH2
Swissprot Q9UBL3
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human ASH2L
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.4mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Alternative splicing results in a shorter isoform 2, designated ASH2L2, which is missing the first 94 amino acid residues found in ASH2L1. Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. ASH2L is highly expressed in fetal liver, testis and leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami. 

 

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