ATF6 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-70158

Overview

Synonyms Activating Transcription Factor 6,CAMP-Dependent Transcription Factor ATF-6 Alpha,Activating Transcription Factor 6 Alpha,Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha,ATF6-Alpha,ACHM7,ATF6A.
Swissprot P18850,F6VAN0,G3V909
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen KLH conjugated Synthetic peptide corresponding to Mouse ATF6
Application IHC
Recommended dilution IHC 1:1000
Concentration 1 mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
Background This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

 

You recently viewed

Clear recently viewed