ATP6V1A Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-65078

Overview

Synonyms 70kDa subunit,ATP6A1,ATP6V1A,ATP6V1A1,ATPase H+ transporting lysosomal subunit A1,ATPase H+ transporting, lysosomal 70kDa V1 subunit A,H(+) transporting two sector ATPase subunit A,H+ transporting ATPase chain A vacuolar (VA68 type),HO68,OTTHUMP00000214746,V ATPase 69 kDa subunit 1,V ATPase A subunit 1,V ATPase subunit A 1,V-ATPase 69 kDa subunit,V-ATPase subunit A,V-type proton ATPase catalytic subunit A,VA68,Vacuolar ATP synthase catalytic subunit A ubiquitous isoform,Vacuolar ATPase isoform VA68,Vacuolar proton pump alpha subunit 1,Vacuolar proton pump subunit alpha,VATA,Vma1,VPP2
Swissprot P38606
Source Rabbit
Reactivity Mouse
Immunogen A synthetic peptide of human ATP6V1A
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist.

 

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