BFAR Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15969

Overview

Synonyms BAR,Bfar,BFAR,Bifunctional apoptosis inhibitor,Bifunctional apoptosis regulator,RING finger protein 47,RNF47
Swissprot Q9NZS9
Source Rabbit
Reactivity Human
Immunogen Synthetic peptide of human BFAR
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background A novel protein, BAR, for bifunctional apoptosis regulator, contains domains that enable it to interact with components of both major apoptosis pathways, where it negatively regulates apoptotic signaling. Like the other anti-apoptosis proteins Bap31 and FLIP, BAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. In addition, BAR contains a domain that also enables it to interact with the mitochondrial Bcl-2 family of proteins. The presence of these various RING, SAM, DED and TM domains suggests that BAR may serve as a scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery.

 

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