Bim Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-30650

Overview

Synonyms BCL2 like 11,B2L11,BAM,Bcl 2 interacting protein Bim,Bcl 2 related ovarian death agonist,Bcl-2-like protein 11,BCL2 interacting mediator of cell death,BCL2 like 11 (apoptosis facilitator),BCL2 like protein 11,Bcl2-interacting mediator of cell death,Bcl2-L-11,Bcl2l11,BIM alpha6,BIM,BIM beta6,BIM beta7,BimEL,BimL,BOD
Swissprot O43521
Source Rabbit
Reactivity Human,Mouse,Rat,Monkey
Immunogen Synthesized peptide derived from the N-terminal region of human Bim
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

 

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