BMPR2 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-14441

Overview

Synonyms BMP type II receptor,BMP type-2 receptor,BMPR 2,BMPR 3,BMPR II,BMPR-2,BMPR-II,Bmpr2,BMPR2,BMPR3,BMPRII,BMR 2,BMR2,Bone morphogenetic protein receptor type 2,Bone morphogenetic protein receptor type II,Bone morphogenetic protein receptor type-2,Bone morphogenic protein receptor type II serine threonine kinase,BRK 3,BRK3,PPH 1,PPH1,Serine threonine kinase type II activin receptor like kinase,T ALK,TALK,Type II activin receptor like kinase
Swissprot Q13873
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human BMPR2
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.2mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

 

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