CCDC88A Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-13059

Overview

Synonyms AKT iphosphorylation enhancer,Akt phosphorylation enhancer,APE,Ccdc88a,Coiled coil domain containing 88A,Coiled coil domain containing protein 88A,Coiled-coil domain-containing protein 88A,FLJ10392,G alpha interacting vesicle associated protein,G alpha-interacting vesicle-associated protein,Galpha interacting vesicle associated protein,Girders of actin filament,Girdin,GIV,GRDN,GRDN,HkRP1,Hook related protein 1,Hook-related protein 1,KIAA1212
Swissprot Q3V6T2
Source Rabbit
Reactivity Human,Mouse
Immunogen Synthetic peptide of human CCDC88A
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

 

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