CD148 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-30147

Overview

Synonyms CD 148,CD148,CD148 antigen,Density enhanced phosphatase 1,Density-enhanced phosphatase 1,DEP 1,DEP-1,HPTP eta,HPTPeta,Human density enhanced phosphatase 1,Protein tyrosine phosphatase eta,Protein tyrosine phosphatase receptor type J,Protein tyrosine phosphatase receptor type J polypeptide,Protein-tyrosine phosphatase eta,Protein-tyrosine phosphatase receptor type J,PTPJ,Ptprj,PTPRJ,R PTP Eta,R-PTP-eta,R-PTP-J,Receptor type tyrosine protein phosphatase eta,Receptor-type tyrosine-protein phosphatase eta,SCC 1,SCC1,susceptibility to colon cancer 1,mouse,homolog of
Swissprot Q12913
Source Rabbit
Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of human CD148.
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000-1:20000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

 

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