CD179b Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-30808

Overview

Synonyms IGLL1,IGL1,Immunoglobulin lambda-like polypeptide 1,CD179 antigen-like family member B,Ig lambda-5,Immunoglobulin omega polypeptide,Immunoglobulin-related protein 14.1,CD antigen CD179b,IGLC1,Ig lambda-1 chain C regions,IGLC2,Ig
Swissprot P15814,P0CG04,P0CG05,P0CG06,P0CF74,A0M8Q6
Source Rabbit
Reactivity Human
Immunogen Synthesized peptide derived from the N-terminal region of human CD179b.
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.IGLL1 (Immunoglobulin Lambda Like Polypeptide 1) is a Protein Coding gene. Diseases associated with IGLL1 include Agammaglobulinemia 2 and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Cell surface interactions at the vascular wall and Primary immunodeficiency. An important paralog of this gene is IGLL5.

 

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