CDC25A Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-70140

Overview

Synonyms Cdc 25a,CDC25A,CDC25A2,CDC25A2 CAG isoform,Cell division cycle 25 homolog A (S. pombe),Cell division cycle 25A,Cell division cycle 25A isoform a,Cell division cycle 25A isoform b,D9Ertd393e,Dual specificity phosphatase Cdc25A,M phase inducer phosphatase 1,M-phase inducer phosphatase 1,MGC115549,MPIP1
Swissprot P30304,P48965,P48964
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen KLH conjugated Synthetic peptide corresponding to Mouse Cdc25A
Application WB,IHC
Recommended dilution WB 1:500-1:1000, IHC 1:1500-1:3000
Concentration 0.96 mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
Background CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. 

 

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