CDC45 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-60574

Overview

Synonyms CDC 45,CDC 45L,CDC45 (cell division cycle 45, S.cerevisiae homolog) like,CDC45,CDC45 cell division cycle 45 like,CDC45 like,CDC45 related protein,CDC45,CDC45L2,Cell division control protein 45 homolog,Cell division cycle 45 like 2,Cell division cycle 45 like,PORC PI 1,PORC-PI-1
Swissprot O75419
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human cdc45
Application WB,IHC
Recommended dilution WB 1:500 - 1:2000 IHC 1:50 - 1:200
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.

 

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