CDK12 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-13172

Overview

Synonyms arginine/serine-rich,Cdc2 related kinase arginine/serine rich,CDC2 related protein kinase 7,Cdc2-related kinase,CDC2-related protein kinase 7,Cdk12,CDK12,Cell division cycle 2 related protein kinase 7,Cell division cycle 2-related protein kinase 7,Cell division protein kinase 12,CRK7,CRKR,CrkRS,Cyclin-dependent kinase 12,EC 2.7.11.22,hCDK12,kiaa0904,Pksc
Swissprot Q9NYV4
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of human CDK12
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.5mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background CrkRS (Cdc2-related kinase, arginine/serine-rich, also designated CRK7 and CRKR) is an ubiquitous protein that appears to localize to the nucleus and link transcription and splicing machinery. CrkRS belongs to the serine/threonine protein kinase family and Cdc2/Cdkx subfamily. CrkRS has extensive proline-rich regions that resemble SH3 and WW domain binding sites, and an RS domain that is characteristic of splicing factors. The protein kinase domain of CrkRS is 89% identical to the CHED protein kinase, also designated CDC2L5 and cell division cycle 2-like 5 (cholinesterase-related cell division controller), however outside the kinase domains the two proteins are unique. Cell cycle control kinases can phosphorylate proteins important for differentiation and apoptosis and provide connections between proliferation, differentiation, apoptosis, and neurocytoskeleton dynamics.

 

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