CENPC Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-14864

Overview

Synonyms CENP-C 1,CENP-C,CENPC,CENPC1,Centromere autoantigen C,Centromere autoantigen C1,Centromere protein C 1,Centromere protein C,hcp-4,ICEN7,Interphase centromere complex protein 7,MIF2
Swissprot Q03188
Source Rabbit
Reactivity Human
Immunogen Recombinant protein of human CENPC
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.6mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

 

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