CHAC1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-11078

Overview

Synonyms Blocks Notch protein,Botch,Cation transport regulator like protein 1,Cation transport regulator-like protein 1,ChaC,ChaC cation transport regulator homolog 1,ChaC cation transport regulator like 1,chac1,CHAC1,Gamma GCT acting on glutathione homolog 1,Gamma-GCG 1,Glutathione-specific gamma-glutamylcyclotransferase 1
Swissprot Q9BUX1
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human CHAC1
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.7mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background CHAC1 (ChaC, cation transport regulator homolog 1 (E. coli)) is a 264 amino acid cytoplasmic protein that belongs to the ChaC family. Induced by chemical activators of the unfolded protein response (UPR) pathway, including DTT, tunicamycin and thapsigargin, CHAC1 is a pro-apoptotic member of this pathway and may mediate the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Overexpression of CHAC1 may lead to an increase in apoptosis, while suppression of CHAC1 results in subdued apoptosis. 

 

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