CLASP1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-30938

Overview

Synonyms 1700030C23Rik,5730583A19Rik,B130045P17Rik,CLAP1,clasp1,CLIP associating protein 1,CLIP associating protein CLASP1,CLIP-associating protein 1,Cytoplasmic linker associated protein 1,Cytoplasmic linker-associated protein 1,DKFZp686D1968,DKFZp686H2039,FLJ33821,FLJ41222,hOrbit1,KIAA0622,MAST1,MGC131895,mKIAA0622,Multiple asters 1,Multiple asters homolog 1,Protein Orbit homolog 1
Swissprot Q7Z460
Source Rabbit
Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the C-terminal region of human CLASP1
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

 

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