Cleaved-F12 HC (R372) Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-30068

Overview

Synonyms Factor XII,Beta factor XIIa part 1,Beta factor XIIa part 2,Coagulation factor XII,Coagulation factor XIIa heavy chain,Coagulation factor XIIa light chain,F12,F12 deficiency,FA12,Factor XII deficiency,HAE3,HAEX,HAF,HAF deficiency,Hageman factor
Swissprot P00748
Source Rabbit
Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of human Factor XII HC
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:20000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.

 

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