Cleaved-F7 LC (R212) Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-30065

Overview

Synonyms coagulation factor VII (serum prothrombin conversion accelerator),Coagulation factor VII,Eptacog alfa,F7,FA7,Factor VII,Factor VII heavy chain,Factor VII light chain,FVII coagulation protein,OTTHUMP00000018733,OTTHUMP00000018734,Proconvertin,Serum prothrombin conversion accelerator,SPCA
Swissprot P08709
Source Rabbit
Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of human Factor VII LC
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

 

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