CNGB1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-30977

Overview

Synonyms 240 kDa protein of rod photoreceptor CNG channel,cGMP gated cation channel beta subunit,CNCG 4,CNCG2,CNCG3L,CNCG4,CNG 4,CNG channel 4,CNG channel beta 1,CNG4,CNGB 1,CNGB1,CNGB1B,Cyclic nucleotide gated cation channel 4,Cyclic nucleotide gated cation channel,Cyclic nucleotide gated cation channel beta 1,Cyclic nucleotide gated cation channel gamma,Cyclic nucleotide gated cation channel modulatory subunit,Cyclic nucleotide gated channel (photoreceptor) cGMP gated 3 (gamma) like,Cyclic nucleotide gated channel beta 1,GAR1,GARP,GARP2,Glutamic acid rich protein,RCNC2,RCNCb,RCNCbeta,RP45,Truncated glutamic acid rich protein,Truncated rod photoreceptor cGMP gated channel beta subunit
Swissprot Q14028
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of human CNG-1β
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene.CNGB1 (Cyclic Nucleotide Gated Channel Beta 1) is a Protein Coding gene. Diseases associated with CNGB1 include Retinitis Pigmentosa 45 and Cngb1-Related Retinitis Pigmentosa. Among its related pathways are Phototransduction and Metabolism of fat-soluble vitamins. GO annotations related to this gene include voltage-gated potassium channel activity and cGMP binding. An important paralog of this gene is CNGB3.

 

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