COX10 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-34382

Overview

Synonyms 2410004F01Rik,AU042636,COX10,COX10,Cytochrome c oxidase assembly protein,Cytochrome c oxidase subunit X,Heme A farnesyltransferase,Heme O synthase,OTTMUSP00000006085,Protoheme IX farnesyltransferase,mitochondrial,Protoheme IX farnesyltransferase,mitochondrial precursor,RP23-78H18.1
Swissprot Q12887
Source Rabbit
Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of human COX10.
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.

 

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