CTNNA1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-10207

Overview

Synonyms Alpha E-catenin,Cadherin associated protein 102kDa,Cadherin associated protein,Cadherin-associated protein,CAP 102,CAP102,Catenin (cadherin associated protein) alpha 1 102kDa,Catenin (cadherin associated protein),alpha 1,102kDa,Catenin alpha 1,Catenin alpha-1,CTNA1,CTNNA 1,Ctnna1,FLJ36832,FLJ52416,MDPT2,NY REN 13 antigen,OTTHUMP00000224141,OTTHUMP00000224147,Renal carcinoma antigen NY REN 13,Renal carcinoma antigen NY-REN-13
Swissprot P35221
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human CTNNA1
Application WB,IHC,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:50-1:200
Concentration 0.2mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be mucHuman, Mouseore dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components.

 

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