Cyclin D3 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-63262

Overview

Synonyms CCND 3,Ccnd3,CCND3,CyclinD3,D3 type cyclin,G1 S specific cyclin D3,G1/S specific cyclin D3,G1/S-specific cyclin-D3
Swissprot P30281
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human CCND3
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

 

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