CYP2D6 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-31109

Overview

Synonyms CPD6,CYP2D,CYP2D6,CYP2D7AP,CYP2D7BP,CYP2D7P2,CYP2D8P2,CYP2DL1,CYPIID6,Cytochrome P450 DB1,Cytochrome P450 family 2 subfamily D member 6,Cytochrome P450 family 2 subfamily D polypeptide 6,Debrisoquine 4 hydroxylase,Flavoprotein linked monooxygenase,Microsomal monooxygenase,P450 DB1,P450C2D,P450DB1,Xenobiotic monooxygenase
Swissprot P10635
Source Rabbit
Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of human CYP2D6.
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:40000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

 

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