CYP46A1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-16370

Overview

Synonyms Cholesterol 24-hydroxylase,CP46,CYP46,cytochrome P450 family 46
Swissprot Q9Y6A2
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of human CYP46A1
Application WB,IHC,ELISA
Recommended dilution WB 1:200-1:1000, IHC 1:25-1:100
Concentration 0.5mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. 

 

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