DCTN4 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-14938

Overview

Synonyms DCTN 4,Dctn4,DCTN4,Dynactin 4 (p62),Dynactin 4,Dynactin p62 subunit,Dynactin subunit 4,Dynactin subunit p62,Dynactin4,p62
Swissprot Q9UJW0
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human DCTN4
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.6mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein . Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end . The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1. Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin . In addition, Dynactin p62 is distributed in the nucleus at very high expression levels . Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton.

 

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