DPPA4 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64808

Overview

Synonyms 2410091M23Rik,Developmental pluripotency associated 4,Developmental pluripotency associated protein 4,Developmental pluripotency-associated protein 4,Dppa 4,DPPA4,DPPA4,FLJ10713
Swissprot Q7L190
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human DPPA4
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

 

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