DUSP12 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-14070

Overview

Synonyms Dual specificity phosphatase 12,Dual specificity protein phosphatase 12,Dual specificity tyrosine phosphatase YVH1,DUS12,DUSP 1,DUSP 12,DUSP1,DUSP12,Serine/threonine specific protein phosphatase,TDSP4,YVH 1,YVH1,YVH1 protein tyrosine phosphatase (S. cerevisiae) ortholog,YVH1 protein tyrosine phosphatase ortholog
Swissprot Q9UNI6
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human DUSP12
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.7mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

 

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