DUT Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15604

Overview

Synonyms Deoxyuridine 5' triphosphate nucleotidohydrolase,nuclear isoform,Deoxyuridine 5'-triphosphate nucleotidohydrolase,mitochondrial,Deoxyuridine triphosphatase,dut,DUT,dUTP nucleotidohydrolase,dUTP pyrophosphatase,dUTPase,FLJ20622
Swissprot P33316
Source Rabbit
Reactivity Human ,Rat
Immunogen Synthetic peptide of human DUT
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

 

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