EGLN1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15294

Overview

Synonyms C1ORF12,Chromosome 1 Open Reading Frame 12,DKFZp761F179,ECYT 3,ECYT3,Egl 9 family hypoxia inducible factor 1,EGL 9 homolog of C. elegans 1,EGL nine (C.elegans) homolog 1,Egl nine homolog 1 (C. elegans),Egl nine homolog 1,Egl nine like protein 1,EGLN 1,Egln1,EGLN1,HIF PH2,HIF Prolyl Hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HIFP4H 2,HIFPH2,HPH 2,HPH-2,HPH2,Hypoxia inducible factor prolyl hydroxylase 2,Hypoxia-inducible factor prolyl hydroxylase 2,ORF13,P4H2,PHD 2,PhD2,PNAS 118,PNAS 137,Prolyl Hydroxylase Domain Containing Protein 2,Prolyl hydroxylase domain-containing protein 2,Rat Homolog of SM20,SM 20,SM-20,SM20,Zinc finger MYND domain containing protein 6,ZMYND6
Swissprot Q9GZT9
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human EGLN1
Application IHC,ELISA
Recommended dilution IHC 1:10-1:50
Concentration 0.1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.

 

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