Overview
| Synonyms | C1ORF12,Chromosome 1 Open Reading Frame 12,DKFZp761F179,ECYT 3,ECYT3,Egl 9 family hypoxia inducible factor 1,EGL 9 homolog of C. elegans 1,EGL nine (C.elegans) homolog 1,Egl nine homolog 1 (C. elegans),Egl nine homolog 1,Egl nine like protein 1,EGLN 1,Egln1,EGLN1,HIF PH2,HIF Prolyl Hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HIFP4H 2,HIFPH2,HPH 2,HPH-2,HPH2,Hypoxia inducible factor prolyl hydroxylase 2,Hypoxia-inducible factor prolyl hydroxylase 2,ORF13,P4H2,PHD 2,PhD2,PNAS 118,PNAS 137,Prolyl Hydroxylase Domain Containing Protein 2,Prolyl hydroxylase domain-containing protein 2,Rat Homolog of SM20,SM 20,SM-20,SM20,Zinc finger MYND domain containing protein 6,ZMYND6 |
| Swissprot | Q9GZT9 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human EGLN1 |
| Application | IHC,ELISA |
| Recommended dilution | IHC 1:10-1:50 |
| Concentration | 0.1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | |
| Tissue specificity | |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. |
