ELAVL1 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-60367

Overview

Synonyms ELAV (embryonic lethal abnormal vision Drosophila) like 1,ELAV (embryonic lethal,abnormal vision,Drosophila) like 1 (Hu antigen R),ELAV like 1,ELAV like RNA binding protein 1,ELAV-like protein 1,ELAV1,ELAV1,Elavl1,Embryonic lethal abnormal vision drosophila homolog like 1,Hu Antigen R,Hu-antigen R,Hua,HuR,MelG
Swissprot Q15717
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human ELAVL1
Application WB,IHC,IF
Recommended dilution WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.

 

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