ERG Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-60276

Overview

Synonyms Avian erythroblastosis virus E-26 (v-ets) oncogene related,D030036I24Rik,Erg 3,Erg,ERG/EWS fusion gene,included,ERG/FUS fusion gene,included,ERG/TMPSSR2 fusion gene,included,ERG,ERG1,included,ERG2,included,ets related,ETS-related gene,KCNH2,Oncogene ERG,p55,TMPRSS2/ERG fusion,transcriptional regulator ERG (transforming protein ERG),Transcriptional regulator ERG,Transforming protein ERG,v ets avian erythroblastosis virus E26 oncogene,v ets avian erythroblastosis virus E26 oncogene related,v ets erythroblastosis virus E26 oncogene homolog,v ets erythroblastosis virus E26 oncogene like,v ets erythroblastosis virus E26 oncogene like isoform 2,v-ets erythroblastosis virus E26 oncogene,v-ets erythroblastosis virus E26 oncogene homolog (avian),V-ets erythroblastosis virus E26 oncogene like (Avian),isoform CRA_e
Swissprot P11308
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human ERG
Application WB,IF
Recommended dilution WB 1:500 - 1:2000 IF 1:50 - 1:200
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined.

 

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