EWSR1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-31388

Overview

Synonyms bK984G1.4,bK984G1.4 Ewing sarcoma breakpoint region 1 protein,Ewing sarcoma breakpoint region 1,Ewing sarcoma breakpoint region 1 protein,Ewings sarcoma EWS Fli1 type 1 oncogene,EWS,EWS oncogene,EWS RNA binding protein 1,EWS,EWSR 1,Ewsr1,EWSR1 protein,RNA binding protein EWS,RNA-binding protein EWS
Swissprot Q01844
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of human EWS
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

 

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