Factor VIII Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-31394

Overview

Synonyms AHF,Antihemophilic factor,Coagulation factor VIII,coagulation factor VIII,procoagulant component,coagulation factor VIIIc,DXS1253E,F8,F8b,F8c,FA8,factor VIII F8B,Factor VIIIa light chain,FactorVIII,FVIII,Hema,Hemophilia A,Hemophilia,classic,OTTHUMP00000061446,OTTHUMP00000196174,Procoagulant component
Swissprot P00451
Source Rabbit
Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the C-terminal region of human Factor VIII
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

 

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