GEMIN2 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-12637

Overview

Synonyms Component of gems 2,Gem (nuclear organelle) associated protein 2,Gem associated protein 2,GEMI2,Gemin-2,gemin2,SIP 1,SIP-1,SIP1,SIP1 delta,SIP1-delta,SMN interacting protein 1,SMN interacting protein 1 delta,SMN-interacting protein 1,Survival interacting protein 1,Survival of motor neuron protein interacting protein 1,Survival of motor neuron protein-interacting protein 1
Swissprot O14893
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of human GEMIN2
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.

 

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