GNRHR Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15701

Overview

Synonyms GnRH receptor,GnRH-R,GNRHR,GNRHR,GNRHR1,Gonadotropin releasing hormone receptor,gonadotropin-releasing hormone (type 1) receptor 1,Gonadotropin-releasing hormone receptor,GRHR,HH7,leutinizing-releasing hormone receptor,lh-rh,LHRHR,LRHR,luliberin receptor,luteinizing hormone releasing hormone receptor,type I GnRH receptor
Swissprot P30968
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of human GNRHR
Application WB,IHC,ELISA
Recommended dilution WB 1:2000-1:5000, IHC 1:150-1:500
Concentration 0.9mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

 

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