GPX4 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64550

Overview

Synonyms Glutathione peroxidase 4,GPX 4,GPX-4,GPX4,GPX4,GSHPx-4,MCSP,mitochondrial,PHGPx,Phospholipid hydroperoxidase,Phospholipid hydroperoxide glutathione peroxidase,Phospholipid hydroperoxide glutathione peroxidase mitochondrial,snGPx,snPHGPx,Sperm nucleus glutathione peroxidase
Swissprot P36969
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human GPX4
Application WB,IHC,IF
Recommended dilution WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

 

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