GREM1 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64081

Overview

Synonyms BMP antagonist 1,Cell proliferation inducing gene 2 protein,Cell proliferation-inducing gene 2 protein,CKTSF1B1,colorectal adenoma and carcinoma 1,Cysteine knot superfamily 1,Cysteine knot superfamily 1,BMP antagonist 1,Cysteine knot superfamily BMP antagonist 1,DAN domain family member 2,DAND2,Down regulated in Mos-transformed cells protein,Down-regulated in Mos-transformed cells protein,DRM,grem1,GREM1,Gremlin 1 homolog,cysteine knot superfamily,Gremlin 1 like protein,Gremlin 1,cysteine knot superfamily,homolog,GREMLIN,Gremlin-1,Gremlin1,IHG-2,IHG2,Increased in high glucose 2,Increased in high glucose protein 2,PIG2,Proliferation inducing gene 2,proliferation inducing gene 2 protein
Swissprot O60565
Source Rabbit
Reactivity Human
Immunogen Recombinant protein of human GREM1
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

 

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