GRK4 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-14112

Overview

Synonyms G protein coupled receptor kinase 4,G protein-coupled receptor kinase 2 (Drosophila)-like,G protein-coupled receptor kinase 4,G protein-coupled receptor kinase GRK4,G proteinm coupled receptor kinase GRK4,GPRK2L,GPRK4,GRK4,GRK4,GRK4a,ITI1
Swissprot P32298
Source Rabbit
Reactivity Human
Immunogen Recombinant protein of human GRK4
Application WB,IHC,ELISA
Recommended dilution WB 1:1000-1:5000, IHC 1:50-1:200
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.

 

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