GRPR Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15663

Overview

Synonyms BB2,Bombesin BB2 receptor,bombesin receptor 2,Gastrin Releasing Peptide Receptor,Gastrin-releasing peptide receptor,GRP preferring bombesin receptor,GRP R,GRP-preferring bombesin receptor,GRP-R,Grp/bombesin receptor,Grpr,GRPR
Swissprot P30550
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of human GRPR
Application WB,ELISA
Recommended dilution WB 1:500-1:2000
Concentration 1.5mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

 

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