HAO1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-35991

Overview

Synonyms (S) 2 hydroxy acid oxidase,Glycolate oxidase,GOX,GOX1,HAO1,HAOX1,HAOX1,Hydroxyacid oxidase 1,MGC142225,MGC142227,OTTHUMP00000030231
Swissprot Q9UJM8
Source Rabbit
Reactivity Mouse,Rat
Immunogen Recombinant Protein
Application WB,IHC-p
Recommended dilution WB 1:2000-5000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Background This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. HAO1 (Hydroxyacid Oxidase 1) is a Protein Coding gene. Diseases associated with HAO1 include Lactocele and Primary Hyperoxaluria. Among its related pathways are Glyoxylate metabolism and glycine degradation and Peroxisome. GO annotations related to this gene include receptor binding and FMN binding. An important paralog of this gene is HAO2.

 

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