HLA-DQB1/2 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-30237

Overview

Synonyms HLA-DQB1,HLA-DQB,HLA class II histocompatibility antigen,DQ beta 1 chain,MHC class II antigen DQB1,HLA-DQB2,HLA-DXB,HLA class II histocompatibility antigen,DQ beta 2 chainHLA class II histocompatibility antigen,DX beta chain,MHC class II antigen DQB2
Swissprot P01920,P05538
Source Rabbit
Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of human HLA-DQB1/2.
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000-1:20000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Alternative splicing results in multiple transcript variants. HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation.

 

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