HMGCR Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15096

Overview

Synonyms 3 hydroxy 3 methylglutaryl CoA reductase,3 hydroxy 3 methylglutaryl Coenzyme A reductase,3 hydroxymethylglutaryl CoA reductase,3-hydroxy-3-methylglutaryl CoA reductase (NADPH),3-hydroxy-3-methylglutaryl-coenzyme A reductase,3H3M,HMDH,HMG CoA reductase,HMG CoAR,HMG-CoA reductase,Hmgcr,Hydroxymethylglutaryl CoA reductase,LDLCQ3,MGC103269,Red
Swissprot P04035
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human HMGCR
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.2mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

 

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