HMGCS1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-16482

Overview

Synonyms 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble),3-hydroxy-3-methylglutaryl coenzyme A synthase,cytoplasmic,EC 2.3.3.10,HMCS1,HMG CoA synthase,HMG-CoA synthase,HMGCS,HMGCS1,Hydroxymethylglutaryl CoA synthase,cytoplasmic,Hydroxymethylglutaryl-CoA synthase,MGC90332
Swissprot Q01581
Source Rabbit
Reactivity Human
Immunogen Synthetic peptide of human HMGCS1
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.6mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.

 

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