IBTK Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-65137

Overview

Synonyms BTKI,IBtk,IBTK,inhibitor of Bruton agammaglobulinemia tyrosine kinase,Inhibitor of Bruton tyrosine kinase
Swissprot Q9P2D0
Source Rabbit
Reactivity Human
Immunogen Recombinant protein of human IBTK
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

 

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