Overview
Synonyms | H IDHG,IDH gamma,IDH3G,IDH3G,Isocitrate dehydrogenase [NAD] subunit gamma,Isocitrate dehydrogenase [NAD] subunit gamma,mitochondrial,Isocitrate dehydrogenase 3 (NAD+) gamma,Isocitric dehydrogenase,Isocitric dehydrogenase subunit gamma,mitochondrial,NAD (H) specific isocitrate dehydrogenase gamma subunit,NAD(+) specific ICDH,NAD(+)-specific ICDH subunit gamma,NAD+ specific ICDH,OTTHUMP00000025984,OTTHUMP00000025985,OTTHUMP00000025987,OTTHUMP00000025988,OTTHUMP00000214764 |
Swissprot | P51553 |
Source | Rabbit |
Reactivity | Human,Mouse,Rat |
Immunogen | Recombinant protein of human IDH3G |
Application | WB,IHC,ELISA |
Recommended dilution | WB 1:500-1:2000, IHC 1:25-1:100 |
Concentration | 0.3mg/mL |
Clonality | Polyclonal |
Properties
Cellular localization | |
Tissue specificity | |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
Background | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. |