KCNA3 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-31889

Overview

Synonyms HGK 5,HGK5,HLK 3,HLK3,HPCN 3,HPCN3,HuKIII,KCNA 3,Kcna3,KCNA3,KV1.3,MK 3,MK3,OTTHUMP00000032397,PCN 3,PCN3,Potassium channel 3,Potassium voltage gated channel shaker related subfamily member 3,Potassium voltage gated channel subfamily A member 3,Potassium voltage-gated channel subfamily A member 3,Type n potassium channel,Voltage gated potassium channel protein Kv1.3,Voltage gated potassium channel subunit Kv1.3,Voltage-gated K(+) channel HuKIII,Voltage-gated potassium channel subunit Kv1.3
Swissprot P22001
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from human Kv1.3 around the non-phosphorylation site of Tyr187.
Application WB,IHC-p,IF,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.KCNA3 (Potassium Voltage-Gated Channel Subfamily A Member 3) is a Protein Coding gene. Diseases associated with KCNA3 include Lymph Node Cancer. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNA2.

 

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