KRAS Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-34261

Overview

Synonyms c Ki ras2,c Kirsten ras protein,c-K-ras,c-Ki-ras,Cellular c Ki ras2 proto oncogene,Cellular transforming proto oncogene,CFC2,cK Ras,GTPase KRas,K RAS p21 protein,K RAS2A,K RAS2B,K RAS4A,K RAS4B,K-Ras 2,KI RAS,Ki-Ras,KIRSTEN MURINE SARCOMA VIRUS 2,Kirsten rat sarcoma 2 viral (v Ki ras2) oncogene homolog,Kirsten rat sarcoma viral oncogene homolog,KRAS,KRAS proto oncogene,GTPase,KRAS1,KRAS2,N-terminally processed,NS,NS3,Oncogene KRAS2,p21ras,PR310 c K ras oncogene,PR310 cK ras oncogene,RALD,RASK,RASK2,Transforming protein p21,v Ki ras2 Kirsten rat sarcoma 2 viral oncogene homolog,v Ki ras2 Kirsten rat sarcoma viral oncogene homolog
Swissprot P01116
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the C-ternal region of human KRAS
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background KRAS,also called p21,is a member of the Ras superfamily of proteins. It is located on human chromosome 12,and contains four coding exons and a 5' non-coding exon (PMID: 12778136). KRAS is a membrane-anchored guanosine triphosphate/guanosine diphosphate (GTP/GDP)-binding protein and is widely expressed in most human cells. Like other members of the Ras family,the KRAS protein is a GTPase,and it is involved in intracellular signal transduction and mainly responsible for EGFR-signaling activation (PMID: 19117687). KRAS mutations have been found in various malignancies,including lung adenocarcinoma,mucinous adenoma,ductal carcinoma of the pancreas and colorectal carcinoma. KRAS has two isoforms,a and b.

 

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