LAT Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-31910

Overview

Synonyms 36 kDa phospho tyrosine adapter protein,36 kDa phospho-tyrosine adapter protein,36 kDa phospho-tyrosine adaptor protein,LAT 1,lat,LAT,LAT1,Linker for activation of T cells,Linker for activation of T cells family member 1,linker for activation of T cells,transmembrane adaptor,Linker for activation of T-cells family member 1,p36 38,p36-38,pp36
Swissprot O43561
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from human LAT around the non-phosphorylation site of Y200.
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:20000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

 

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