LZTS2 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-65047

Overview

Synonyms hLZTS2,KIAA1813,LAPSER1,Leucine zipper putative tumor suppressor 2,LZTS2,LZTS2,OTTHUMP00000020289,Protein LAPSER1,RP11-108L7.8
Swissprot Q9BRK4
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human LZTS2
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants.

 

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