MAL Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-16590

Overview

Synonyms mal,MAL protein gene,Mal T-cell differentiation protein,MAL,MALGENE,MPV17,Myelin and lymphocyte protein,T-cell differentiation protein MAL,T-lymphocyte maturation-associated protein,VIP17
Swissprot P21145
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of human MAL
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.7mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.

 

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