Overview
| Synonyms | mal,MAL protein gene,Mal T-cell differentiation protein,MAL,MALGENE,MPV17,Myelin and lymphocyte protein,T-cell differentiation protein MAL,T-lymphocyte maturation-associated protein,VIP17 |
| Swissprot | P21145 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human MAL |
| Application | IHC,ELISA |
| Recommended dilution | IHC 1:50-1:200 |
| Concentration | 0.7mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | |
| Tissue specificity | |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. |
