MCM3 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-40230

Overview

Synonyms Cervical cancer proto oncogene 5,DNA polymerase alpha holoenzyme associated P1,HCC 5,HCC5,hRlf beta subunit,Human cervical cancer proto oncogene 5,MCM 3,MGC1157,Minichromosome maintenance complex component 3,P1 h,P1 MCM3,P1.h,p102,Replication licensing factor beta subunit, RLF beta subunit,RLFB
Swissprot P25205
Source Rabbit
Reactivity Human
Immunogen Recombinant Human DNA replication licensing factor MCM3 protien
Application IHC
Recommended dilution IHC 1:50-1:200
Concentration 2mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
Background The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with mCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.

 

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